Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 86, Issue 3, Pages 226-231Publisher
WILEY
DOI: 10.1038/sj.icb.7100132
Keywords
naive T cells; memory T cells; migration; trafficking
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Our established understanding of lymphocyte migration suggests that naive and memory T cells travel throughout the body via divergent pathways; naive T cells circulate between blood and lymph whereas memory T cells additionally migrate through non-lymphoid organs. Evidence is now gradually emerging which suggests such disparate pathways between naive and memory T cells may not strictly be true, and that naive T cells gain access to the non-lymphoid environment in numbers approaching that of memory T cells. We discuss here the evidence for naive T-cell traffic into the non-lymphoid environment, compare and contrast this movement with what is known of memory T cells, and finally discuss the functional importance of why naive T cells might access the parenchymal tissues.
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