Journal
ACTA PHYSIOLOGICA
Volume 192, Issue 1, Pages 19-28Publisher
WILEY
DOI: 10.1111/j.1748-1716.2007.01780.x
Keywords
FOXO transcription factors; longevity; p53; SIRT1; stress stimuli; tumour suppression
Categories
Funding
- NATIONAL CANCER INSTITUTE [T32CA009302] Funding Source: NIH RePORTER
- NCI NIH HHS [T32 CA009302] Funding Source: Medline
Ask authors/readers for more resources
Ageing is associated with an increased onset of cancer. Understanding the molecular mechanisms that underlie the age dependency of cancer will have important implications for preventing and treating this pathology. The signalling pathway connecting insulin and FOXO transcription factors provides the most compelling example for a conserved genetic pathway at the interface between ageing and cancer. FOXO transcription factors (FOXO) promote longevity and tumour suppression. FOXO transcription factors are directly phosphorylated in response to insulin/growth factor signalling by the protein kinase Akt, thereby causing their sequestration in the cytoplasm. In the absence of insulin/growth factors, FOXO factors translocate to the nucleus where they trigger a range of cellular responses, including resistance to oxidative stress, a phenotype highly coupled with lifespan extension. FOXO factors integrate stress stimuli via phosphorylation, acetylation and mono-ubiquitination of a series of regulatory sites. Understanding how FOXO proteins integrate environmental conditions to control specific gene expression programmes will be pivotal in identifying ways to slow the onset of cancer in ageing individuals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available