Journal
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 23, Issue 2, Pages 121-125Publisher
HINDAWI LTD
DOI: 10.1155/2009/431349
Keywords
Crohn's disease; Inflammatory bowel diseases; Infliximab therapy; Ulcerative colitis; Smoking
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Crohn's disease (CD) is an idiopathic inflammatory bowel disease and has no known cure. CD symptoms are treated using an array of medicines, including biological agents such as infliximab. However, infliximab therapy is expensive; therefore, identifying variables that can help predict response to infliximab is worthwhile. The present article reviews the impact of tobacco smoking on the efficacy of infliximab in CID. Earlier studies have speculated that smoking has a negative effect on the response to infliximab in CID, but the Current literature is largely unable to identify a significant relationship between the two. Although smoking is known to have a negative effect or the course of CD, as well as other organ systems, presently, a CD patient's smoking status should not influence treatment decisions regarding infliximab therapy.
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