Journal
APOPTOSIS
Volume 13, Issue 1, Pages 1-9Publisher
SPRINGER
DOI: 10.1007/s10495-007-0154-9
Keywords
autophagy; apoptosis; Bcl-2; FADD; Atg5
Categories
Funding
- NATIONAL CANCER INSTITUTE [R01CA111421, P30CA046934] Funding Source: NIH RePORTER
- NCI NIH HHS [P30 CA046934, R01 CA111421, R01 CA111421-04] Funding Source: Medline
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Apoptosis and autophagy are genetically-regulated, evolutionarily-conserved processes that regulate cell fate. Both apoptosis and autophagy are important in development and normal physiology and in a wide range of diseases. Recent studies show that despite the marked differences between these two processes, their regulation is intimately connected and the same regulators can sometimes control both apoptosis and autophagy. In this review, I discuss some of these findings, which provide possible molecular mechanisms for crosstalk between apoptosis and autophagy and suggest that it may be useful to think of these processes as different facets of the same cell death continuum rather than completely separate processes.
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