Journal
NEUROSCIENTIST
Volume 14, Issue 5, Pages 422-433Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858408317955
Keywords
Extracellular potassium concentration; Epilepsy; Neocortex; Hippocampus; Glia; Astrocytes; Dynamics; Computational model; Tonic-clonic seizures
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Funding
- NIDCD [5R01 DC006300]
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC006306] Funding Source: NIH RePORTER
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The role of changes in the extracellular potassium concentration [K+](o) in epilepsy has remained unclear Historically, it was hypothesized that [K+](o) is the causal factor for epileptic seizures. This so-called potassium accumulation hypothesis led to substantial debate but subsequently failed to find wide acceptance. However, recent studies on the pathophysiology of tissue from epileptic human patients and animal epilepsy models revealed aberrations in [K+](o) regulation. Computational models of cortical circuits that include ion concentration dynamics have catalyzed a renewed interest in the role of [K+](o) in epilepsy. The authors here connect classical and more recent insights on [K+](o) dynamics in the cortex with the goal of providing starting points for a next generation of [K+](o) research. Such research may ultimately lead to an entirely new class of antiepileptic drugs that act on the [K+](o) regulation system. NEUROSCIENTIST 14(5):422-433, 2008. DOI: 10.1177/1073858408317955
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