Exercise in migraine treatment. Review and discussion of clinical trials and implications for further trials

Regular exercise is recommended in general treatment guidelines for migraine. However, scientific evidence in support of this recommendation is weak. The majority of available trials on this topic do not meet modern requirements for randomized clinical trials. Often the diagnosis of migraine is not certain, the duration of treatment is too short, and the intervention is not clearly defined; furthermore, the control of treatment is insufficient. The study results are controversial regarding the efficiency of sports intervention in migraine. Regular exercises may have specific effects on the course of disease in migraine through increase of fitness or relaxing effects. It remains unclear whether exercise alone is efficient in migraine treatment or only as part of a more multidisciplinary program. Theoretical considerations, the available limited studies, and clinical experience suggest that exercise may have an effect on migraine, but the present knowledge does not fulfill the needs of evidence-based medicine. Future studies should adhere to the rules for randomized clinical trials in pharmacological migraine prophylaxis.