Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 28, Issue 1, Pages 14-20Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-007-9127-6
Keywords
dendritic cells; aging; PI3 kinase; cytokines
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Funding
- NIA NIH HHS [AG027512] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R21AG027512] Funding Source: NIH RePORTER
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Dendritic cells are central to the generation of both immunity and tolerance. This review focuses on the alterations in the functions of dendritic cells in aged and its consequences on both tolerance and immunity. We have discussed certain mechanisms responsible for the defective dendritic cell function associated with aging.
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