Journal
EXPERT REVIEW OF OPHTHALMOLOGY
Volume 3, Issue 1, Pages 97-109Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1586/17469899.3.1.97
Keywords
fludarabine; neurotoxicity; ocular toxicity; ophthalmic pathology; pharmacogenetics; purine analog
Categories
Funding
- NEI Intramural Research Program
- NATIONAL EYE INSTITUTE [Z01EY000222, ZICEY000461] Funding Source: NIH RePORTER
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The purine analogs, fludarabine and cladribine represent an important class of chemotherapy agents used to treat a broad spectrum of lymphoid malignancies. Their toxicity profiles include dose-limiting myelosuppression, immunosuppression, opportunistic infection and severe neurotoxicity. This review summarizes the neurotoxicity of high-and standard-dose fludarabine, focusing on the clinical and pathological manifestations in the eye. The mechanisms of ocular toxicity are probably multifactorial. With increasing clinical use, an awareness of the neurological and ocular vulnerability, particularly to fludarabine, is important owing to the potential for life-and sight-threatening consequences.
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