Journal
PHARMACOLOGY
Volume 81, Issue 1, Pages 18-20Publisher
KARGER
DOI: 10.1159/000107663
Keywords
cannabinoid; CB1 receptor; Delta(9)-tetrahydrocannabinol; memory extinction
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The cannabinoid Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is currently being employed or tested for a number of therapeutic uses. Cannabinoid CB1 receptors are critically involved in adverse memory extinction. It is not known whether an unintended effect of Delta(9)-THC is increased extinction rates of adverse memories. We therefore tested the effect of Delta(9)-THC on adverse memory extinction using an auditory-stimulus/ foot shock paradigm. We found that repeated administration of a high dose of Delta(9)-THC over 6 days retarded extinction compared with controls. This is in contrast to other reports and might be a result of endocannabinoid signalling dysfunction due to cannabinoid receptor densensitization. Copyright (C) 2008 S. Karger AG, Basel.
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