Journal
PHARMACOLOGY
Volume 81, Issue 2, Pages 151-157Publisher
KARGER
DOI: 10.1159/000110787
Keywords
diabetes; hyperalgesia; streptozotocin; indomethacin; celecoxib; cyclooxygenase; nitric oxide inhibitors; streptozotocin-induced hyperalgesia, rats
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We examined a possible involvement of cyclooxygenase (COX) and nitric oxide synthase (NOS) products in hyperalgesia occurring during streptozotocin (STZ)-induced diabetes. Indomethacin and celecoxib were used as relatively selective inhibitors of COX-1 and COX-2, respectively. NOS inhibitors included: non-specific inhibitor N-G-nitro-L-arginine and L-N-6-(1-iminoethyl)lysine preferentially acting on inducible NOS (iNOS) as well as 7-nitroindazole relatively specific inhibitor neuronal NOS (nNOS). The above-mentioned agents, except 7-nitroindazole, suppressed hyperalgesia occurring after administration of STZ. The results of the study suggest participation of COX-1, COX-2 and iNOS, but not nNOS, in transmission of pain stimuli in STZ-induced diabetic hyperalgesia. Copyright (C) 2008 S. Karger AG, Basel.
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