Journal
MYCOPATHOLOGIA
Volume 165, Issue 1, Pages 51-59Publisher
SPRINGER
DOI: 10.1007/s11046-007-9076-x
Keywords
Fusarium graminearum; magnesium; transcriptional control; trichothecenes
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Growth and production of type-B trichothecenes mycotoxins by the Fusarium graminearum strain CBS 185.32 were compared in GYEP medium supplemented with Mg2+ at different concentrations (0 - 4 mM). Mg2+ led to a strong decrease in toxin accumulation without affecting the mycelial growth, suggesting a specific Mg2+ effect on fungal secondary metabolism. Expression of Tri5, Tri6, and Tri12 genes was followed throughout the time courses of type-B trichothecenes (TCTB) yield in standard and 2 mM Mg2+-supplemented GYEP media. Mg2+ addition significantly decreased Tri5, Tri6, and Tri12 expression. The inhibition of toxin production by Mg2+ was shown to be highly correlated with inhibition of Tri5 transcription and, to a lesser extend, of Tri6 and Tri12. This is the first report of a transcriptional control of TCTB production by Mg2+.
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