Journal
ACS CHEMICAL BIOLOGY
Volume 11, Issue 3, Pages 654-668Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.5b00942
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Funding
- National Institutes of Health [GM079357, GM110394, CA151304]
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The post-translational modification of arginine residues represents a key mechanism for the epigenetic, control of gene expression. Aberrant levels of histone arginine modifications have been linked to the development of several diseases including cancer. In recent years, great progress has been made in understanding the physiological role of individual arginine modifications and their effects on chromatin function. The present review aims to summarize the structural and functional aspects of histone arginine modifying enzymes and their impact on gene transcription. We will discuss the potential for targeting these proteins with small molecules in a variety of disease states.
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