Journal
CANADIAN JOURNAL OF CHEMISTRY
Volume 92, Issue 10, Pages 987-995Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/cjc-2014-0034
Keywords
ormosil; hybrid coating; biomaterial; sol-gel; stent; vascular cells
Categories
Funding
- Sao Paulo Research Foundation (FAPESP)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenadoria de Aperfeicoamentos do Pessoal do Ensino Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado da Bahia (FAPESB)
- FAPESP [2006/53266-4, 2003/09578-3, 2011/18271-5, 2010/10674-0, 2011/07376-0]
- CNPq [308123/2009-3]
- FAPESB [PPP0039/2010]
- CAPES
- CNPq
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [10/10674-0, 11/07376-0] Funding Source: FAPESP
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Surface coating of metallic materials using the sol-gel technique is a suitable approach to obtain hybrid materials with improved properties for biomedical applications. In this study, an AISI 316L stainless steel surface was coated with ormosils prepared from tetraethylsiloxane and 3-glycidoxypropyltrimethoxysilane or polydimethylsiloxane. The characterization of structural and surface properties was performed by several techniques. Surface microstructure, morphology, and energy are dependent on organosilane type and content. Chemical stability of coatings was investigated by static immersion tests in phosphate buffer solution at 37 degrees C, and silicon leaching after 21 days was found to be in the range of similar to 200-300 mu g L-1. Mechanical adhesion was found to be within 1.0 and 3.7 N cm(-1). The interaction of the samples and materials in the cardiovascular environment was investigated through cellular behavior. Biological assays were performed with slides to avoid any cytotoxic effects on human endothelial cells (HUVEC) and rabbit arterial smooth muscle cells (RASM). No significant alterations were observed after 24 h in the viability of RASM and HUVEC cells exposed to different coatings. No increase of HUVEC or RASM migration was observed after 24 h as evaluated by transwell migration assay. The hybrid materials showed suitable properties for potential application as biomaterials in cardiovascular environment as well as for incorporation of bioactive species with the aim to prepare drug-eluting stents.
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