Journal
CANADIAN JOURNAL OF CHEMISTRY
Volume 90, Issue 10, Pages 851-857Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/v2012-078
Keywords
cucurbit[7]uril (CB[7]); benzethonium; host-guest complex; hydrophobic; hydrophilic
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
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The sequential complexations of the hydrophilic and hydrophobic end groups of benzethonium chloride by cucurbit[7]uril (CB[7]) in aqueous solution have been investigated using H-1 NMR spectroscopy and electrospray ionization mass spectrometry. The initial binding is to the benzyldimethylammonium group, with a stability constant of (8.7 +/- 3.1) x 10 (7)(mol/L)(-1). This binding constant and the complexation-induced upfield shifts of the benzyl guest protons are similar to those values observed with other cationic guests containing benzyl moieties. This equilibrium is followed by the binding of a second equivalent of the host to the hydrophobic 2-(2,4,4-trimethylpentyl) group, with a stability constant of (4.0 +/- 1.9) x 10 (3) (mol/L)(-1). The relatively strong binding of this uncharged hydrophobic end of the guest molecule is consistent with the inclusion of eight heavy (nonhydrogen) atoms within the inner cavity of CB[7], with its low polarizability. The packing coefficient for the 2-(2,4,4-trimethylpentyl) group with the inner cavity is calculated to be 61%, close to Rebek's ideal value of 55%.
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