Journal
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
Volume 89, Issue 1, Pages 72-76Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/V10-157
Keywords
pseurotin A; Aspergillus fumigatus; structure elucidation; cytotoxicity
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Funding
- National Natural Science Foundation of China [40906076]
- Shandong Provincial Natural Science Fund [ZR2009CZ016]
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Two new metabolites containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione core, pseurotin A(1) (1) and A(2) (2), as well as pseurotin A (3), were isolated from the holothurian-derived fungus Aspergillus fumigatus WFZ-25. These compounds were determined using extensive analysis of their spectroscopic data, including 1D and 2D NMR, HR-ESI-MS, and circular dichroism (CD) experiments.
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