Journal
CANADIAN JOURNAL OF CHEMISTRY
Volume 89, Issue 1, Pages 57-60Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/V10-159
Keywords
biofouling; antifouling; Cladiella krempfi; Balanus amphitrite; diterpenes
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Funding
- Centre for Marine Living Resources and Ecology (CMLRE), Ministry of Earth Sciences, New Delhi
- Council of Scientific and Industrial Research (CSIR), Government of India
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Bioassay-guided purification of methanol extract of the soft coral Cladiella krempfi (Octocorallia: Alcynocea) yielded a novel eunicellin-type diterpenoid, (-)-6 alpha-hydroxy polyanthellin A (1), active against the cyprids of the fouling barnacle, Balanus amphitrite (EC50 9.02 mu g/mL; LC50 36 mu g/mL; and therapeutic ratio = 4). The structure of compound 1 was determined from its spectral data, including IR, NMR (1D and 2D NMR), and mass spectra.
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