Journal
CANADIAN JOURNAL OF CHEMISTRY
Volume 87, Issue 3, Pages 486-489Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/V09-006
Keywords
cytochalasin; Spicaria elegans; cytochrome P-450 inhibitor; cytotoxicity
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Funding
- Chinese National Natural Science Fund [30772640]
- Shandong Province [Z2006C13]
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Treatment of Spicaria elegans with cytochrome P-450 inhibitor resulted in two new deoxy-cytochalasins, 7-deoxy-cytochalasin Z(7) (1) and 7-deoxy-cytochalasin Z(9) (2), which were recognized as plausible precursors of cytochalasins Z(7) and Z(9), respectively. Their structures were elucidated by spectroscopic methods and the absolute configuration of 1 was determined by the conventional Mosher ester method. Their cytotoxicities against two cancer cell lines were evaluated.
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