Journal
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
Volume 64, Issue -, Pages 83-89Publisher
BLACKWELL PUBLISHING
DOI: 10.1107/S0907444907033938
Keywords
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Funding
- Biotechnology and Biological Sciences Research Council [BB/D522403/1] Funding Source: Medline
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Molecular replacement is a powerful tool for the location of large models using structure-factor magnitudes alone. When phase information is available, it becomes possible to locate smaller fragments of the structure ranging in size from a few atoms to a single domain. The calculation is demanding, requiring a six-dimensional rotation and translation search. A number of approaches have been developed to this problem and a selection of these are reviewed in this paper. The application of one of these techniques to the problem of automated model building is explored in more detail, with particular reference to the problem of sequencing a protein main-chain trace.
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