Journal
JOURNAL OF ADDICTIVE DISEASES
Volume 27, Issue 2, Pages 11-17Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1300/J069v27n02_02
Keywords
HIV infection; HCV infection; HIV/HCV co-infection; neurocognition
Categories
Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH019535] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R24NS038841] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA013799] Funding Source: NIH RePORTER
- NIDA NIH HHS [R01 DA13799, R01 DA013799, R01 DA013799-04] Funding Source: Medline
- NIMH NIH HHS [T32 MH019535, U24 MH100929] Funding Source: Medline
- NINDS NIH HHS [R24 NS038841-10, R24 NS038841] Funding Source: Medline
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Due to similar routes of viral transmission, many individuals infected with the human immunodeficiency virus (HIV) are also infected with the hepatitis C virus (HCV). Each virus can cause cognitive compromise among mono-infected individuals; evidence is accumulating that HIV/HCV co-infection may have a particularly deleterious impact on cognition. We present neuropsychological data obtained from 118 HIV+ adults with advanced HIV disease,, 35 of whom were co-infected with HCV, who completed a comprehensive neurocognitive evaluation.. Rates of global cognitive impairment were higher among co-infected patients than among those with HIV alone (63% vs. 43%). Within the specific domains of learning and memory, co-infected individuals were significantly more likely to be impaired than were the HIV mono-infected participants. Finally, we discuss implications of these findings and potential future directions for research in this area.
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