Journal
CANADIAN JOURNAL OF ANIMAL SCIENCE
Volume 99, Issue 2, Pages 244-253Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/cjas-2018-0063
Keywords
propyl propane thiosulfonate (PTSO); gastrointestinal tract simulation; bioavailability; pig digestion
Categories
Funding
- Center for Industrial Technological Development (CDTI) of the Ministry of Industry, Economy and Competitiveness - European Union (FEDER Funds) through the Operational Program for Intelligent Growth
Ask authors/readers for more resources
This paper evaluates the bioavailability of allium derivative propyl propane thiosulfonate (PTSO) in the pig gastrointestinal tract by means of an in vitro dynamic gastrointestinal tract simulator system (GITSS). The GITSS is based on a membrane bioreactor comprising a continuous stirred-tank reactor connected in series to a continuous plug-flow tubular reactor. Bioavailability values have been evaluated for different vehiculization strategies, including mere carriers such as polyethylene glycol sorbitan monooleate (a nonionic surfactant also known as Tween 80) and encapsulation matrices (beta-cyclodextrin vs. mono-and di-glycerides of edible fatty acids mixed with hydrogenated sunflower oil) and compared with the absorption of free PTSO. The net absorbed amount of PTSO in the GITSS when Tween 80 was used as a carrier was over 3.5 times higher than the one for free PTSO. Neither the encapsulated PTSO in beta-cyclodextrin nor by means of mono-and di-glycerides of fatty acids plus a vegetable oil succeeded to improve absorption values for free PTSO. These promising results indicate that Tween 80 provides an interesting and high resistance to the PTSO molecule against the simulated digestive conditions in the stomach, and thus it enables favorably the subsequent absorption process of PTSO along the intestine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available