Journal
CRITICAL REVIEWS IN IMMUNOLOGY
Volume 28, Issue 6, Pages 485-511Publisher
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.v28.i6.20
Keywords
transplantation; accommodation; MHC class I; cell survival; endothelial cell
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Funding
- National Institute of Allergy and Infectious Diseases [RO1 AI 42819]
- National Heart, Lung and Blood Institute [RO1 HL 090995]
- National Science Foundation Graduate Research Fellowship Award
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL090995] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI042819] Funding Source: NIH RePORTER
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The ligation of MHC class I molecules by class I antibodies on endothelial cells leads to both proliferation and survival signal transduction. This signaling pathway has been implicated in the development of acute and chronic antibody-mediated rejection. The ability of a graft to acquire resistance to immune-mediated graft injury is the basis of accommodation. The mechanisms of MHC class I-induced accommodation are unknown, but under certain circumstances following the ligation of MHC class I molecules by antibodies, the survival pathway is activated. This review explores what is currently known about accommodation and how MHC class I signaling may play a role in the process of enhancing graft survival.
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