Journal
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
Volume 61, Issue 6, Pages 558-562Publisher
SPRINGER
DOI: 10.1007/s12630-014-0148-3
Keywords
Sevoflurane; Sufentanil; Rocuronium; Atracurium; Anaphylactic Reaction
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AimTo report rapid recovery from grade IV rocuronium-induced anaphylaxis with a large dose of sugammadex administered early after the onset of symptoms.Clinical featuresA 22-yr-old female without relevant medical history developed an anaphylactic reaction within three minutes of rocuronium injection at induction of anesthesia for a routine cholecystectomy. During the first six minutes, she was unresponsive to usual treatment and her condition evolved to a grade IV anaphylaxis reaction despite a cumulated dose of epinephrine 0.7 mg. Sugammadex 14 mg center dot kg(-1), injected six minutes after rocuronium, resulted in total resolution of all manifestations of anaphylaxis within three minutes. The patient was discharged from hospital the next day. Allergy investigations confirmed rocuronium as the cause of anaphylaxis.ConclusionVery early administration of a large dose of sugammadex may be an effective treatment for rocuronium-induced anaphylaxis.
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