Journal
AGING NEUROPSYCHOLOGY AND COGNITION
Volume 15, Issue 5, Pages 627-641Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/13825580802036936
Keywords
metabolic syndrome; cognitive function; hypertension; memory; verbal learning; global cognition
Funding
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [U01AT001653] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [T32AG000037, R01AG017160] Funding Source: NIH RePORTER
- NCCIH NIH HHS [U01-AT001653, U01 AT001653-01, U01 AT001653] Funding Source: Medline
- NIA NIH HHS [5-T32-AG00037, T32 AG000037-22, R01 AG017160, T32 AG000037, R01-AG17160, R01 AG017160-01A1] Funding Source: Medline
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Objective: Few studies have addressed whether the metabolic syndrome (MetS) and its individual components are associated with cognitive function in middle-aged and older populations, as well as whether specific areas of cognition are more affected than others. We examined the cross-sectional association between MetS and six areas of cognitive function in healthy cognitively intact adults without diabetes (n = 853, mean age 61 years) randomized in two intervention trials. Methods: The National Cholesterol Education Program (NCEP) criteria were used to identify subjects with MetS. Cognitive function was assessed with a neuropsychological battery. A principal components analysis was used to extract five uncorrelated factors interpreted to represent five areas of cognition, and a measure of global cognition was calculated. Results: MetS was weakly but non-significantly associated with lower verbal learning (beta= -.14 [SE(beta) = 0.09], p = .15). As the number of MetS criteria increased, scores on global cognition (p trend = .01), verbal learning (p trend = .06) and semantic memory (p trend = .04) decreased. Hypertension was the only MetS risk factor that was independently correlated with lower verbal learning (beta= -.17 [SE(beta) = 0.08], p = .04), semantic memory (beta= -.26 [SE(beta) = 0.08], p = .001) and global cognition (beta= -.15 [SE(beta) = 0.07], p = .04). Conclusion: This study adds to the evidence of an association between MetS and lower cognitive function among healthy middle-aged and older adults without CVD and diabetes, as well as confirms the correlation between hypertension and lower cognition.
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