Journal
RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY
Volume 2, Issue 3, Pages 159-165Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/187221308786241929
Keywords
Heme oxygenase-1; carbon monoxide; bilirubin; biliverdin; heme; inflammation; allergy; asthma; allergic rhinitis; atopic dermatitis
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Funding
- Korea Health 21 R&D Project, Ministry of Health Welfare [A010251]
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Cumulative evidence suggests that the induction of the antioxidant/anti-inflammatory heme oxygenase (HO)-1 may play a protective role in allergic inflammation. HO-1 suppresses mast cell degranulation and cytokine synthesis. The up-regulation of the HO-1 pathway has a significant protective effect against airway inflammation, mucus hypersecretion, and hyper-responsiveness in a model of allergic asthma. Moreover, HO-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells. The precise underlying mechanisms for HO-1 based protection against allergic inflammation are not yet completely understood, but appear to involve the protective effects of HO-1 by-products, such as carbon monoxide ( CO), biliverdin/bilirubin and free iron. Among the HO-1 by-products, CO has been shown to mimic some protective actions of HO-1 in allergic inflammations. This article reviews the latest knowledge, recent patent and studies on the protective roles and mechanisms of HO-1/CO in inflammation and allergy.
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