Journal
CALCIFIED TISSUE INTERNATIONAL
Volume 95, Issue 6, Pages 495-505Publisher
SPRINGER
DOI: 10.1007/s00223-014-9917-9
Keywords
Osteoarthritis; Molecular mechanisms; Potential therapeutic approches
Categories
Funding
- National Natural Science Foundation of China [81202710]
- Science Technology Department of Zhejiang Province [2011R50022-01, 2012C13017-2]
- Program for Zhejiang Leading Team of ST Innovation
- Key Laboratory of Zhejiang Province
- Zhejiang Chinese Medical University
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Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Because the precise molecular mechanisms which are involved in the degradation of cartilage matrix and development of OA are poorly understood and there are currently no effective interventions to decelerate the progression of OA or retard the irreversible degradation of cartilage except for total joint replacement surgery. In this paper, the important molecular mechanisms related to OA pathogenesis will be summarized and new insights into potential molecular targets for the prevention and treatment of OA will be provided.
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