Journal
CA-A CANCER JOURNAL FOR CLINICIANS
Volume 58, Issue 2, Pages 97-110Publisher
WILEY
DOI: 10.3322/CA.2007.0003
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Funding
- NCI NIH HHS [U54 CA119338, U54 CA 119338, P50 CA128613, U01 CA 101244, R01 CA 112643] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [U01CA101244, P50CA128613, U54CA119338, R01CA112643] Funding Source: NIH RePORTER
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Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment. This technology has enabled the development of nanoscale devices that can be conjugated with several functional molecules simultaneously, including tumor-specific ligands, antibodies, anticancer drugs, and imaging probes. Since these nanodevices are 100 to 1,000-fold smaller than cancer cells, they can be easily transferred through leaky blood vessels and interact with targeted tumor-specific proteins both on the surface of and inside cancer cells. Therefore, their application as cancer cell-specific delivery vehicles will be a significant addition to the currently available armory for cancer therapeutics and imaging.
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