Journal
BURNS
Volume 39, Issue 1, Pages 98-104Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.burns.2012.05.021
Keywords
Chitosan; Poly(vinyl alcohol); Healing; Hydrogel; Histological analyses; Primary Irritation Index; Ocular Irritation Index
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Funding
- International Atomic Energy Agency (IAEA) [14520]
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Hydrogel based on poly(vinyl alcohol) containing 0.25% of chitosan was synthesized by gamma irradiation and evaluated as wound dressing material in a burn rat model. Histological analyses, Primary Irritation Index (P.I.I.) and Ocular Irritation Index (O.I.I.) were investigated. The comparative study showed that the wounds treated with PVA/chitosan hydrogel healed on the 9th day, while those treated with paraffin gauze dressing and cotton gauze healed on the 16th day. Histological analysis showed that new granulation tissue and epithelialization progressed better in wound treated with hydrogel PVA/chitosan. The determined values of P.I.I. and O.I.I. of the PVA/chitosan hydrogel were, respectively 0.5 and zero. These values indicate that the PVA/chitosan hydrogel can be considered as non-irritating to the skin.(C) 2012 Elsevier Ltd and ISBI. All rights reserved.
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