Journal
BURNS
Volume 36, Issue 4, Pages 450-460Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.burns.2009.08.016
Keywords
Human skin; Tissue engineering; Dermo-epidermal substitute; Keratinocyte stem cells; Vascularization
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The engineering of skin substitutes and their application on human patients has become a reality. However, cell biologists, biochemists, technical engineers, and surgeons are still struggling with the generation of complex skin substitutes that can readily be transplanted in large quantities, possibly in only one surgical intervention and without significant scarring. Constructing a dermo-epidermal substitute that rapidly vascularizes, optimally supports a stratifying epidermal graft on a biodegradable matrix, and that can be conveniently handled by the surgeon, is now the ambitious goal. After all, this goal has to be reached coping with strict safety requirements and the harsh rules of the economic market. (C) 2009 Elsevier Ltd and ISBI. All rights reserved.
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