Journal
BURNS
Volume 35, Issue 1, Pages 46-50Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.burns.2008.05.007
Keywords
ADM; Porcine; Histological structure; Biocompatibility
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Funding
- National High Technology Research and Development Program of China [2006AA02A121]
- National Key Research Project of the 10th five-year-plan of China [2004BA717B-03]
- Zongshen Junhui Biotech Company
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The present study was to compare the difference of histological structure and biocompatibility between human ADM and porcine ADM. The scaffold structure, collagen arrangement and collagen structure of human ADM and those of porcine ADM were very similar except for a slight difference in their black and white bands assessed by both light microscopy and electron microscopy. The positive immunohistochemical staining results of porcine ADM using human antibodies of collagen 1, collagen 111, collagen IV, fibronectin, laminin and vimentin and the result of SDS-PAGE implied a strong homology between the main proteins of human ADM and porcine ADM. In addition, statistical analysis indicated that there was no significant difference (P < 0.05) between the biocompatibility of the two ADMs. Based on these results, we conclude that porcine ADM bears a strong similarity to human ADM, and might be a substitute for human ADM in the future. (C) 2008 Elsevier Ltd and ISBI. All rights reserved.
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