Journal
BURNS
Volume 35, Issue 1, Pages 51-57Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.burns.2008.07.018
Keywords
Integra (R); Matriderm (R); Dermal replacement (R); Reconstructive surgery (R)
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Funding
- University of Zurich or University Children Hospital of Zurich
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Aim: To compare engraftment rates and vascularisation in a rat model using either Integra Artificial Skin (R) or Matriderm (R). Methods: Matriderm (R) and the dermal part of Integra (R) were compared in a two-step procedure including matrix implantation and subsequent epidermal grafting. Neonatal rat epidermis was used as coverage to test for rapid and complete take. Results: Efficiency and quality of vascularisation expressed by take rate of epidermis, and thickness of resulting neodermis, were identical for both matrices. Conclusion: This first comparison of Matriderm (R) with Integra (R) in a rat model revealed no major differences in engraftment rates or vascularisation. (C) 2008 Elsevier Ltd and ISBI. All rights reserved.
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