Journal
BURNS
Volume 35, Issue 1, Pages 98-103Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.burns.2008.04.005
Keywords
Scald; Endothelin-1; Cerebral artery; Rat
Categories
Funding
- Natural Science Foundation of Jiangxi Province [0440062]
- Science Foundation of Jiangxi Provincial Department of Education [2007-80]
Ask authors/readers for more resources
The purpose of this study was to investigate the influences of scald on endothelin-1 (ET-1) expression in cerebral vessels of rats, and to further elucidate the relationship between changes of ET-1 expression and scald-induced cerebral vascular remodelling resulting in cerebral vasospasm. The ET-1 levels in the cerebral basilar arteries were estimated by radioimmunoassay. Expression of ET-1 and its mRNA were determined by Western blotting and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. Changes of cerebral basilar artery histology were observed and diameters were measured by angiography. The results showed that the ET-1 levels at 3 h after scald were enhanced, peaking at 12 h; the expression of ET-1 mRNA was also enhanced, peaking at 6 h. Simultaneous vascular remodelling was observed in the cerebral basilar arteries, vasoconstriction peaking at 12 h. It is suggested that ET-1 plays an important role in the pathogenesis of scald-induced cerebral vasospasm and cerebral circulation disorder. Crown Copyright (C) 2008 Published by Elsevier Ltd and ISBI. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available