Journal
PSYCHO-ONCOLOGY
Volume 17, Issue 1, Pages 9-18Publisher
WILEY
DOI: 10.1002/pon.1192
Keywords
breast cancer; insomnia; depression; mood; vasomotor symptoms; night sweats; hot flashes; quality of life
Funding
- NCI NIH HHS [CA112035, R01 CA112035, R01 CA069375-10, R01 CA069375-05S4, R01 CA069375-03, R01 CA069375-07, R01 CA069375-05S2, R01 CA069375-04S2, R01 CA069375-04, R01 CA069375-05, R01 CA069375-08, R01 CA069375-02, R01 CA069375-06, R01 CA069375-04S1, R01 CA069375-02S1, R01 CA069375, CA69375, R01 CA069375-05S3, R01 CA069375-04S3, R01 CA069375-06S1, R01 CA069375-09, R01 CA069375-04S4, R01 CA069375-05S5, R01 CA069375-06S2, R01 CA069375-05S1, R01 CA069375-03S1] Funding Source: Medline
- NCRR NIH HHS [M01-RR00079, M01-RR00070, M01 RR000079, M01 RR000827, M01-RR00827, M01 RR000070] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA069375, R01CA112035] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000827, M01RR000070, M01RR000079] Funding Source: NIH RePORTER
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Background. Many individual risk factors for insomnia have been identified for women with a history of breast cancer. We assessed the relative importance of a wide range of risk factors for insomnia in this population. Methods: Two thousand six hundred and forty-five women <= 4 years post-treatment for Stage I (>= 1 cm)-IIIA breast cancer provided data on cancer-related variables, personal characteristics, health behaviors, physical health/symptoms, psychosocial variables, and the Women's Health Initiative-Insomnia Rating Scale (WHI-IRS; scores >= 9 indicate clinically significant insomnia). Results: Thirty-nine per cent had elevated WHI-IRS scores. In binary logistic regression, the variance in high/low insomnia group status accounted for by each risk factor category was: cancer-specific variables, 0.4% (n.s.); personal characteristics, 0.9% (n.s.); health behaviors, 0.6% (n.s.); physical health/symptoms, 13.4% (p<0.001); and, psychosocial factors, 11.4% (p<0.001). Insomnia was associated with worse depressive (OR = 1.32) and vasomotor symptoms (particularly night sweats) (OR = 1.57). Conclusion: Various cancer-specific, demographic, health behavior, physical health, and psychosocial factors have been previously reported as risk factors for insomnia in breast cancer. In our study (which was powered for simultaneous examination of a variety of variables), cancer-specific, health behavior, and other patient variables were not significant risk factors when in the presence of physical health and psychosocial variables. Only worse depressive and vasomotor symptoms were meaningful predictors. Copyright (C) 2007 John Wiley & Sons, Ltd.
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