Journal
JOURNAL OF BACTERIOLOGY
Volume 190, Issue 1, Pages 438-441Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01373-07
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063790] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM063790-06] Funding Source: Medline
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Shiga toxin 2 (Stx2), one of the principal virulence factors of enterohemorrhagic Escherichia coli, is encoded by 933W, a lambda-like prophage. 933W prophage induction contributes to Stx2 production, and here, we provide evidence that Dam methyltransferase is essential for maintenance of 933W lysogeny. Our findings are consistent with the idea that the 933W prophage has a relatively low threshold for induction, which may promote Stx2 production during infection.
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