Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 390, Issue 5, Pages 1227-1240Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-007-1641-0
Keywords
supersaturated designs; set-up; data interpretation; analytical application
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For screening purposes, two-level screening designs, such as fractional factorial (FF) and Plackett-Burman (PB) designs, are usually applied. These designs enable examination of, at most, N-1 factors in N experiments. However, when many factors need to be examined, the number of experiments still becomes unfeasibly large. Occasionally, in order to reduce time and costs, a given number of factors can be examined in fewer experiments than with the above screening designs, by using supersaturated designs. These designs examine more than N-SS-1 factors in N-SS experiments. In this review, different set-ups to construct supersaturated designs are explained and discussed, followed by several possible data interpretations of supersaturated design results. Finally, some analytical applications of supersaturated designs are given.
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