Journal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume 49, Issue 1, Pages 380-389Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.07-0065
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- NEI NIH HHS [R01 EY 05034] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY005034] Funding Source: NIH RePORTER
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PURPOSE. To test the hypothesis that intraretinal Po-2 increases after photocoagulation. METHODS. Anesthetized cats underwent retinal argon laser photocoagulation. At least 4 weeks after treatment, Po-2-sensitive microelectrodes were used to record intraretinal Po-2 profiles from healed photocoagulation lesions in anesthetized cats breathing air. Histopathologic examination of the retinas was used to confirm that the photoreceptors were destroyed and that the inner retinal layers were preserved, though somewhat disorganized, as in human panretinal photocoagulation (PRP). RESULTS. The retina and tapetum were thinner in the lesioned retina than in the nonphotocoagulated retina. Average Po-2 across the inner 50% of the retina was higher (22 +/- 10 mm Hg) in photocoagulated retina than in untreated retina (14 +/- 7 mm Hg; P < 0.01; n = 13 cats). The minimum Po-2 was also significantly higher, whereas choroidal Po-2 was significantly lower in the photocoagulated retina than in untreated retina. No significant difference was found in the preretinal vitreous. After lesions, inner retinal Po-2 could also be maintained above zero, even in the absence of retinal circulation. CONCLUSIONS. Previous measurements showed increased Po-2 in the preretinal vitreous of rabbits and pigs (but not cats) after photocoagulation of the outer retina. These intraretinal measurements in cats provide further evidence for a chronic increase in inner retinal Po-2 in lesioned areas during air breathing.
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