Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 390, Issue 1, Pages 169-179Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-007-1619-y
Keywords
capillary electrophoresis; chemometrics; optimization; experimental design; response surface methodology
Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R15AI065468] Funding Source: NIH RePORTER
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A critical review of recent developments in the use of chemometric experimental design based optimization techniques in capillary electrophoresis applications is presented. Current advances have led to enhanced separation capabilities of a wide range of analytes in such areas as biological, environmental, food technology, pharmaceutical, and medical analysis. Significant developments in design, detection methodology and applications from the last 5 years (2002-2007) are reported. Furthermore, future perspectives in the use of chemometric methodology in capillary electrophoresis are considered.
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