Journal
FEBS LETTERS
Volume 582, Issue 2, Pages 385-390Publisher
WILEY
DOI: 10.1016/j.febslet.2007.11.085
Keywords
ACE; ACE2; collectrin; calmodulin; shedding
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Angiotensin-converting enzyme-2 (ACE2) is a regulatory protein of the renin-angiotensin system (RAS) and a receptor for the causative agent of severe-acute respiratory syndrome (SARS), the SARS-coronavirus. We have previously shown that ACE2 can be shed from the cell surface in response to phorbol esters by a process involving TNF-alpha converting enzyme (TACE; ADAM17). In this study, we demonstrate that inhibitors of calmodulin also stimulate shedding of the ACE2 ectodomain, a process at least partially mediated by a metalloproteinase. We also show that calmodulin associates with ACE2 and that this interaction is decreased by calmodulin inhibitors. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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