Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 390, Issue 2, Pages 617-628Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-007-1717-x
Keywords
LC-MS-MS; mycotoxins; ochratoxin A; patulin; stable isotope dilution assay; trichothecenes
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The principle and applications of stable isotope dilution assays (SIDAs) in mycotoxin analysis are critically reviewed. The general section includes historical aspects of SIDAs, the prerequisites and limitations of the use of stable isotopically labelled internal standards, and possible calibration procedures. In the application section actual SIDAs for the analysis of trichothecenes, zearalenone, fumonisins, patulin, and ochratoxin A are presented. The syntheses and availability of labelled mycotoxins for use as internal standards is reviewed and specific advances in food analysis and toxicology are demonstrated. The review indicates that LC-MS applications, in particular, require the use of stable isotopically labelled standards to compensate for losses during clean-up and for discrimination due to ion suppression. As the commercial availability of these compounds continues to increase, SIDAs can be expected to find expanding use in mycotoxin analysis.
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