Journal
FEBS LETTERS
Volume 582, Issue 2, Pages 229-232Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.12.005
Keywords
TRP channel; TRPA1; cholecystokinin release; calcium
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TRPA1 channels are non-selective cation channels activated by plant derived pungent products including allyl isothiocyanate (AITC) from mustard. Therefore, possible intestinal secretory functions of these channels were investigated. We detected TRPA1 mRNA in mouse and human duodenal mucosa and in intestinal mouse neuroendocrine STC-1 cells. Stimulation of STC-1 cells with AITC increased intracellular calcium (vertical bar Ca(2+)vertical bar(j)) and significantly stimulated cholecystokinin secretion by 6.7-fold. AITC induced cholecystokinin release was completely blocked by TRPA1 antagonist ruthenium red and depletion of extracellular calcium and reduced by 36% by nimodipine and nifedipine. This suggests that spices in our daily food might stimulate digestive functions. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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