Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 83, Issue 1, Pages 172-176Publisher
WILEY
DOI: 10.1038/sj.clpt.6100450
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Osteoporosis is characterized by low bone mass with skeletal fragility and an increased risk of fracture. This bone loss is brought about by an imbalance between bone resorption and formation. Cathepsin K is the most abundant cysteine protease expressed in the osteoclast and is believed to be instrumental in bone matrix degradation necessary for bone resorption. Cathepsin K inhibitors represent a novel target for developing agents to treat osteoporosis and other disorders characterized by increased bone resorption.
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