Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 84A, Issue 1, Pages 178-190Publisher
WILEY
DOI: 10.1002/jbm.a.31268
Keywords
biomechanics; mouse carotid artery; pressurization; noncontacting measurement; stereomicroscope; 3D-digital image correlation; stereocalibration
Funding
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016461] Funding Source: NIH RePORTER
- NCRR NIH HHS [P20 RR-016461] Funding Source: Medline
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A stereomicroscope system is adapted to make accurate, quantitative displacement, and strain field measurements with microscale spatial resolution and nanoscale displacement resolution on mouse carotid arteries. To perform accurate and reliable calibration for these systems, a two-step calibration process is proposed and demonstrated using a modification to recently published procedures. Experimental results demonstrate that the microscope system with three-dimensional digital image correlation (3D-DIC) successfully measures the full 3D displacement and surface strain fields at the microscale during pressure cycling of 0.40-mm-diameter mouse arteries, confirming that the technique can be used to quantify changes in local biomechanical response which may result from variations in extracellular matrix composition, with the goal of quantifying properties of the vessel. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res 84A: 178-190, 2008.
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