Journal
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Volume 295, Issue 4, Pages F867-F876Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.90264.2008
Keywords
tight junction; paracellular; permeability
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases [RO1-DK-062283]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK062283] Funding Source: NIH RePORTER
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Claudins are a family of tight junction membrane proteins that regulate paracellular permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are expressed throughout the renal tubule, and mutations in two claudin genes are now known to cause familial hypercalciuric hypomagnesemia with nephrocalcinosis. In this review, we discuss recent advances in our understanding of the physiological role of various claudins in normal kidney function, and in understanding the fundamental biology of claudins, including the molecular basis for selectivity of permeation, claudin interactions in tight junction formation, and regulation of claudins by protein kinases and other intracellular signals.
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