Journal
CARDIOVASCULAR RESEARCH
Volume 77, Issue 4, Pages 667-675Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvm048
Keywords
sarcomere; assembly
Categories
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL062426] Funding Source: NIH RePORTER
- NHLBI NIH HHS [P01 HL 62426] Funding Source: Medline
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The assembly of sarcomeric proteins into the highly organized structure of the sarcomere is an ordered and complex process involving an array of structural and associated proteins. The sarcomere has shown itself to be considerably more complex than ever envisaged and may be considered one of the most complex macromolecular assemblies in biology. Studies over the last decade have helped to put a new face on the sarcomere, and, as such, the sarcomere is being redefined as a dynamic network of proteins capable of generating force and signalling with other cellular compartments and metabolic enzymes capable of controlling many facets of striated myocyte biology.
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