Journal
NEUROPSYCHOPHARMACOLOGY
Volume 33, Issue 1, Pages 84-87Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.npp.1301610
Keywords
autism; fragile x; metabotropic glutamate receptor; cerebral protein synthesis; synaptic plasticity; developmental disorder
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [F30MH067431] Funding Source: NIH RePORTER
- NIMH NIH HHS [F30 MH067431] Funding Source: Medline
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Fragile X is a synapsopathy-a disorder of synaptic function and plasticity. Recent studies using mouse models of the disease suggest that the critical defect is altered regulation of synaptic protein synthesis. Various strategies to restore balanced synaptic protein synthesis have been remarkably successful in correcting widely varied mutant phenotypes in mice. Insights gained by the study of synaptic plasticity in animal models of fragile X have suggested novel therapeutic approaches, not only for human fragile X but also for autism and mental retardation of unknown etiology.
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