Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 1, Pages 73-79Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7433-z
Keywords
limb regeneration; cell migration; wound healing; wound epidermis; positional information; blastema; dedifferentiation
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Upon amputation of the urodele limb, the epidermal cells surrounding the amputation plane migrate to heal the wound. The resulting wound epidermis (WE) induces the regeneration process, resulting in blastema formation, cell division, and ultimately repatterning into a new limb. Despite its central role in the initiation of limb regeneration, little is known about how the WE forms. Here we discuss various models of WE formation and the experimental data in support of each.
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