Journal
NATURE GENETICS
Volume 40, Issue 1, Pages 26-28Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2007.41
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Funding
- MRC [MC_U127527198, G0301096] Funding Source: UKRI
- Medical Research Council [G0301096, MC_U127527198] Funding Source: Medline
- Chief Scientist Office [CZB/4/449] Funding Source: Medline
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We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P=4.44x10(-14)).
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