Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 86, Issue 1, Pages 1-10Publisher
WILEY-LISS
DOI: 10.1002/jnr.21437
Keywords
mGluR; phosphorylation; protein kinase; protein phosphatase; desensitization; endocytosis; synaptic plasticity
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [ZIANS003036, Z01NS003036] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
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Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function. (c) 2007Wiley-Liss, Inc.
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