Journal
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
Volume 34, Issue 1, Pages 231-236Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.5012/bkcs.2013.34.1.231
Keywords
Silver nanoparticles; Toxicology; Biomimetic; Vesicle; Dark field microscopy
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Funding
- Kwangwoon University
- National Research Foundation of Korea [NRF-2010-0007050]
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Some cytotoxicity studies for the interpretation of the interaction between nanoparticles and cells are non-mechanistic and time-consuming. Therefore, non-biological screening methods, which are faster and simpler than in-vivo and in-vitro methods, are required as alternatives to current cytotoxicity tests. Here, we proposed a simple screening method for the analysis of the interaction between several AgNPs (bare-, citrate-, and polyvinylpyrrolidone-coating) and dye-containing vesicles acting as a biomimetic cell-membrane. The interaction between AgNPs and vesicles could be evaluated readily by UV-vis spectra. Absorbance deviation in UV-vis spectra revealed a large attraction between neighboring particles and vesicles. This was confirmed by (Derjagin, Landau, Verwey, and Overbeek) theory and MT (dark-field microscopy) analysis. This proposed method might be useful for analyzing the cytotoxicity of nanoparticles with cell-membranes instead of in vitro or in vivo cytotoxicity tests.
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