Journal
NEUROPSYCHOPHARMACOLOGY
Volume 33, Issue 1, Pages 141-165Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.npp.1301563
Keywords
development; dopamine; GABA; glutamate; prefrontal cortex; working memory
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Funding
- NIMH NIH HHS [MH051234, MH043784, MH045156] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH045156, R01MH043784, R37MH043784] Funding Source: NIH RePORTER
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The core features of schizophrenia include deficits in cognitive processes mediated by the circuitry of the dorsolateral prefrontal cortex ( DLPFC). These deficits are associated with a range of molecular and morphological alterations in the DLPFC, each of which could be a cause, consequence, or compensation in relation to other changes, and thus reflect the neuroplasticity of the brain in response to the underlying disease process. In this review, we consider disturbances in excitatory, inhibitory, and modulatory connections of DLPFC circuitry from the perspective of disease- and development-related neuroplasticity and discuss their implications for the identification of novel therapeutic targets.
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