Journal
PSYCHOPHARMACOLOGY
Volume 195, Issue 4, Pages 591-603Publisher
SPRINGER
DOI: 10.1007/s00213-007-0950-5
Keywords
addiction; stress; relapse; CRF; CRH; reinstatement; cocaine; self-administration; anxiety
Categories
Funding
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA017328, R01DA015758] Funding Source: NIH RePORTER
- NIDA NIH HHS [R01 DA015758, R01 DA015758-01, R01 DA015758-05, R01 DA017328, DA15758, R01 DA015758-04, DA17328, R01 DA015758-02, R01 DA015758-03] Funding Source: Medline
Ask authors/readers for more resources
Rationale Stressful events during periods of drug abstinence likely contribute to relapse in cocaine-dependent individuals. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing factor (CRF) responsiveness. Objectives This study examined stressor- and CRF-induced cocaine seeking and other stress-related behaviors in rats with different histories of cocaine self-administration (SA). Materials and methods Rats self-administered cocaine under short-access (ShA; 2 h daily) or long-access (LgA; 6 h daily) conditions for 14 days or were provided access to saline and were tested for reinstatement by a stressor (electric footshock), cocaine or an icv injection of CRF and for behavioral responsiveness on the elevated plus maze, in a novel environment and in the light-dark box after a 14- to 17-day extinction/withdrawal period. Results LgA rats showed escalating patterns of cocaine SA and were more susceptible to reinstatement by cocaine, EFS, or icv CRF than ShA rats. Overall, cocaine SA increased activity in the center field of a novel environment, on the open arms of the elevated plus maze, and in the light compartment of a light-dark box. In most cases, the effects of cocaine SA were dependent on the pattern/amount of cocaine intake with statistically significant differences from saline self-administering controls only observed in LgA rats. Conclusions When examined after several weeks of extinction/withdrawal, cocaine SA promotes a more active pattern of behavior during times of stress that is associated with a heightened susceptibility to stressor-induced cocaine-seeking behavior and may be the consequence of augmented CRF regulation of addiction-related neurocircuitry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available